Recent Publications

A compilation of recent publications in the field of complement research and from members of Complement UK

University of Bath

The Journal Biomolecules (IF 4.1) are announcing a Special Issue focusing on a variety of aspects related to Complement in Human Disease. Original research manuscripts and reviews dealing with the topics outlined in the flyer are very welcome. For more information, please follow this link: https://www.mdpi.com/journal/biomolecules/special_issues/complement_system

Guest Editors: Prof. Jean van den Elsen (bssjmhve@bath.ac.uk) & Dr. Maisem Laabei (ml418@bath.ac.uk)

Paper reference

The Impact of Complement Genes on the Risk of Late-Onset Alzheimer’s Disease

Describes a deep-dive into complement gene associations with AD; shows that Clu and CR1 account for most of the complement-related risk.

Paper authors

Sarah M Carpanini 1 2, Janet C Harwood 3, Emily Baker 1, Megan Torvell 1 2, The Gerad Consortium, Rebecca Sims 3, Julie Williams 1, B Paul Morgan 1 2

33804666

Paper reference

Prognostic Value of Complement Properdin in Cancer

Paper authors

Alessandro Mangogna 1, Praveen M Varghese 2 3, Chiara Agostinis 1, Salman H Alrokayan 4, Haseeb A Khan 4, Cordula M Stover 5, Beatrice Belmonte 6, Anna Martorana 7, Giuseppe Ricci 1 8, Roberta Bulla 9, Uday Kishore 2

33542722

Paper reference

The allosteric modulation of complement C5 by knob domain peptides

Paper authors

Alex Macpherson 1 2, Maisem Laabei 2, Zainab Ahdash 1, Melissa A Graewert 3, James R Birtley 1, Monika-Sarah Ed Schulze 1, Susan Crennell 2, Sarah A Robinson 4, Ben Holmes 1, Vladas Oleinikovas 1, Per H Nilsson 1 5 6, James Snowden 1, Victoria Ellis 1, Tom Eirik Mollnes 6 7 8, Charlotte M Deane 4, Dmitri Svergun 3, Alastair Dg Lawson 1, Jean Mh van den Elsen 2 9

33570492

Paper reference

Complement activity is regulated in C3 glomerulopathy by IgG-factor H fusion proteins with and without properdin targeting domains

Paper authors

Alyssa C Gilmore 1, Yuchun Zhang 2, H Terence Cook 1, Deborah P Lavin 1, Suresh Katti 2, Yi Wang 2, Krista K Johnson 2, SungKwon Kim 2, Matthew C Pickering 3

33129896

Paper reference

C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus

Paper authors

Praveen M Varghese 1 2, Valarmathy Murugaiah 1, Nazar Beirag 1, Nigel Temperton 3, Haseeb A Khan 4, Salman H Alrokayan 4, Mohammed N Al-Ahdal 5, Beatrice Nal 1, Futwan A Al-Mohanna 6, Robert B Sim 7, Uday Kishore 1

33488586

Paper reference

Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target

Paper authors

Chiara Agostinis 1, Andrea Balduit 2, Alessandro Mangogna 1, Gabriella Zito 1, Federico Romano 1, Giuseppe Ricci 1 3, Uday Kishore 4, Roberta Bulla 2

33505394

Paper reference

Prognostic Implications of the Complement Protein C1q in Gliomas.

Paper authors

Alessandro Mangogna 1 , Beatrice Belmonte 2 , Chiara Agostinis 3 , Paola Zacchi 1 , Domenico Gerardo Iacopino 4 , Anna Martorana 5 , Vito Rodolico 5 , Deborah Bonazza 6 , Fabrizio Zanconati 6 , Uday Kishore 7 , Roberta Bulla 1

31649675

Paper reference

Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer’s disease

Shows that increased synapse loss in retina and in hippocampus is a common feature of AD mouse models and is, at least in part, complement driven.

Paper authors

Ryan J Bevan 1 2, Tim R Hughes 2 3, Pete A Williams 4, Mark A Good 5, B Paul Morgan 2 3, James E Morgan 6

33287900

Paper reference

Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species

Describes a panel of novel mAbs that block terminal pathway activation in multiple species by targeting C7 or C7-containing complexes; shows that inhibition downstream of C5 is an attractive target for future therapies.

Paper authors

1. Zelek WM, Morgan BP.

33424866

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