Recent Publications

A compilation of recent publications in the field of complement research and from members of Complement UK

University of Bath

The Journal Biomolecules (IF 4.1) are announcing a Special Issue focusing on a variety of aspects related to Complement in Human Disease. Original research manuscripts and reviews dealing with the topics outlined in the flyer are very welcome. For more information, please follow this link: https://www.mdpi.com/journal/biomolecules/special_issues/complement_system

Guest Editors: Prof. Jean van den Elsen (bssjmhve@bath.ac.uk) & Dr. Maisem Laabei (ml418@bath.ac.uk)

Paper reference
Insights Into the Structure-Function Relationships of Dimeric C3d Fragments.
The paper shows that C3 cleavage results in the spontaneous formation of C3b dimers and reveals that these dimers could modulate B cell activation to influence tolerogenic pathways.
Paper authors
Ayla A Wahid, Rhys W Dunphy, Alex Macpherson, Beth G Gibson, Liudmila Kulik, Kevin Whale, Catherine R Back, Thomas M Hallam, Bayan Alkhawaja, Rebecca L Martin, Ingrid P Meschede, Alastair DG Lawson, V Michael Holers, Andrew G Watts, Susan J Crennell, Claire L Harris, Kevin J Marchbank and Jean MH van den Elsen
34434196
Paper reference
The Impact of Complement Genes on the Risk of Late-Onset Alzheimer’s Disease
Describes a deep-dive into complement gene associations with AD; shows that Clu and CR1 account for most of the complement-related risk.
Paper authors
Sarah M Carpanini 1 2, Janet C Harwood 3, Emily Baker 1, Megan Torvell 1 2, The Gerad Consortium, Rebecca Sims 3, Julie Williams 1, B Paul Morgan 1 2
33804666
Paper reference
Prognostic Value of Complement Properdin in Cancer
Paper authors
Alessandro Mangogna 1, Praveen M Varghese 2 3, Chiara Agostinis 1, Salman H Alrokayan 4, Haseeb A Khan 4, Cordula M Stover 5, Beatrice Belmonte 6, Anna Martorana 7, Giuseppe Ricci 1 8, Roberta Bulla 9, Uday Kishore 2
33542722
Paper reference
The allosteric modulation of complement C5 by knob domain peptides
Paper authors
Alex Macpherson 1 2, Maisem Laabei 2, Zainab Ahdash 1, Melissa A Graewert 3, James R Birtley 1, Monika-Sarah Ed Schulze 1, Susan Crennell 2, Sarah A Robinson 4, Ben Holmes 1, Vladas Oleinikovas 1, Per H Nilsson 1 5 6, James Snowden 1, Victoria Ellis 1, Tom Eirik Mollnes 6 7 8, Charlotte M Deane 4, Dmitri Svergun 3, Alastair Dg Lawson 1, Jean Mh van den Elsen 2 9
33570492
Paper reference
Complement activity is regulated in C3 glomerulopathy by IgG-factor H fusion proteins with and without properdin targeting domains
Paper authors
Alyssa C Gilmore 1, Yuchun Zhang 2, H Terence Cook 1, Deborah P Lavin 1, Suresh Katti 2, Yi Wang 2, Krista K Johnson 2, SungKwon Kim 2, Matthew C Pickering 3
33129896
Paper reference
C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus
Paper authors
Praveen M Varghese 1 2, Valarmathy Murugaiah 1, Nazar Beirag 1, Nigel Temperton 3, Haseeb A Khan 4, Salman H Alrokayan 4, Mohammed N Al-Ahdal 5, Beatrice Nal 1, Futwan A Al-Mohanna 6, Robert B Sim 7, Uday Kishore 1
33488586
Paper reference
Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target
Paper authors
Chiara Agostinis 1, Andrea Balduit 2, Alessandro Mangogna 1, Gabriella Zito 1, Federico Romano 1, Giuseppe Ricci 1 3, Uday Kishore 4, Roberta Bulla 2
33505394
Paper reference
Prognostic Implications of the Complement Protein C1q in Gliomas.
Paper authors
Alessandro Mangogna 1 , Beatrice Belmonte 2 , Chiara Agostinis 3 , Paola Zacchi 1 , Domenico Gerardo Iacopino 4 , Anna Martorana 5 , Vito Rodolico 5 , Deborah Bonazza 6 , Fabrizio Zanconati 6 , Uday Kishore 7 , Roberta Bulla 1
31649675
Paper reference
Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer’s disease
Shows that increased synapse loss in retina and in hippocampus is a common feature of AD mouse models and is, at least in part, complement driven.
Paper authors
Ryan J Bevan 1 2, Tim R Hughes 2 3, Pete A Williams 4, Mark A Good 5, B Paul Morgan 2 3, James E Morgan 6
33287900

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