Recent Publications

A compilation of recent publications in the field of complement research and from members of Complement UK

University of Bath

The Journal Biomolecules (IF 4.1) are announcing a Special Issue focusing on a variety of aspects related to Complement in Human Disease. Original research manuscripts and reviews dealing with the topics outlined in the flyer are very welcome. For more information, please follow this link: https://www.mdpi.com/journal/biomolecules/special_issues/complement_system

Guest Editors: Prof. Jean van den Elsen (bssjmhve@bath.ac.uk) & Dr. Maisem Laabei (ml418@bath.ac.uk)

Describes a deep-dive into complement gene associations with AD; shows that Clu and CR1 account for most of the complement-related risk.
Paper authors
Sarah M Carpanini 1 2, Janet C Harwood 3, Emily Baker 1, Megan Torvell 1 2, The Gerad Consortium, Rebecca Sims 3, Julie Williams 1, B Paul Morgan 1 2
33804666
Paper authors
Alessandro Mangogna 1, Praveen M Varghese 2 3, Chiara Agostinis 1, Salman H Alrokayan 4, Haseeb A Khan 4, Cordula M Stover 5, Beatrice Belmonte 6, Anna Martorana 7, Giuseppe Ricci 1 8, Roberta Bulla 9, Uday Kishore 2
33542722
Paper authors
Alex Macpherson 1 2, Maisem Laabei 2, Zainab Ahdash 1, Melissa A Graewert 3, James R Birtley 1, Monika-Sarah Ed Schulze 1, Susan Crennell 2, Sarah A Robinson 4, Ben Holmes 1, Vladas Oleinikovas 1, Per H Nilsson 1 5 6, James Snowden 1, Victoria Ellis 1, Tom Eirik Mollnes 6 7 8, Charlotte M Deane 4, Dmitri Svergun 3, Alastair Dg Lawson 1, Jean Mh van den Elsen 2 9
33570492
Paper authors
Alyssa C Gilmore 1, Yuchun Zhang 2, H Terence Cook 1, Deborah P Lavin 1, Suresh Katti 2, Yi Wang 2, Krista K Johnson 2, SungKwon Kim 2, Matthew C Pickering 3
33129896
Paper authors
Praveen M Varghese 1 2, Valarmathy Murugaiah 1, Nazar Beirag 1, Nigel Temperton 3, Haseeb A Khan 4, Salman H Alrokayan 4, Mohammed N Al-Ahdal 5, Beatrice Nal 1, Futwan A Al-Mohanna 6, Robert B Sim 7, Uday Kishore 1
33488586
Paper authors
Chiara Agostinis 1, Andrea Balduit 2, Alessandro Mangogna 1, Gabriella Zito 1, Federico Romano 1, Giuseppe Ricci 1 3, Uday Kishore 4, Roberta Bulla 2
33505394
Paper authors
Alessandro Mangogna 1 , Beatrice Belmonte 2 , Chiara Agostinis 3 , Paola Zacchi 1 , Domenico Gerardo Iacopino 4 , Anna Martorana 5 , Vito Rodolico 5 , Deborah Bonazza 6 , Fabrizio Zanconati 6 , Uday Kishore 7 , Roberta Bulla 1
31649675
Shows that increased synapse loss in retina and in hippocampus is a common feature of AD mouse models and is, at least in part, complement driven.
Paper authors
Ryan J Bevan 1 2, Tim R Hughes 2 3, Pete A Williams 4, Mark A Good 5, B Paul Morgan 2 3, James E Morgan 6
33287900
Describes a panel of novel mAbs that block terminal pathway activation in multiple species by targeting C7 or C7-containing complexes; shows that inhibition downstream of C5 is an attractive target for future therapies.
Paper authors
1. Zelek WM, Morgan BP.
33424866

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