Recent Publications

A compilation of recent publications in the field of complement research and from members of Complement UK

University of Bath

The Journal Biomolecules (IF 4.1) are announcing a Special Issue focusing on a variety of aspects related to Complement in Human Disease. Original research manuscripts and reviews dealing with the topics outlined in the flyer are very welcome. For more information, please follow this link: https://www.mdpi.com/journal/biomolecules/special_issues/complement_system

Guest Editors: Prof. Jean van den Elsen (bssjmhve@bath.ac.uk) & Dr. Maisem Laabei (ml418@bath.ac.uk)

Staphylococcus aureus is an opportunistic pathogen that is able to thwart an effective host immune response by producing a range of immune evasion molecules, including S. aureus binder of IgG (Sbi) which interacts directly with the central complement component C3, its fragments and associated regulators. Recently we reported the first structure of a disulfide-linked human C3d17C dimer and highlighted its potential role in modulating B-cell activation. Here we present an X-ray crystal structure of a disulfide-linked human C3d17C dimer, which undergoes a structurally stabilising N-terminal 3D domain swap when in complex with Sbi. These structural studies, in combination with circular dichroism and fluorescence spectroscopic analyses, reveal the mechanism underpinning this unique helix swap event and could explain the origins of a previously discovered N-terminally truncated C3dg dimer isolated from rat serum. Overall, our study unveils a novel staphylococcal complement evasion mechanism which enables the pathogen to harness the ability of dimeric C3d to modulate B-cell activation.
Paper authors
Rhys W. Dunphy1, Ayla A. Wahid1, Catherine R. Back1, Rebecca L. Martin2, Andrew G. Watts2, Charlotte A. Dodson2, Susan J. Crennell1 and Jean M. H. van den Elsen1,3*
35693766
The paper shows that C3 cleavage results in the spontaneous formation of C3b dimers and reveals that these dimers could modulate B cell activation to influence tolerogenic pathways.
Paper authors
Ayla A Wahid, Rhys W Dunphy, Alex Macpherson, Beth G Gibson, Liudmila Kulik, Kevin Whale, Catherine R Back, Thomas M Hallam, Bayan Alkhawaja, Rebecca L Martin, Ingrid P Meschede, Alastair DG Lawson, V Michael Holers, Andrew G Watts, Susan J Crennell, Claire L Harris, Kevin J Marchbank and Jean MH van den Elsen
34434196
Describes a deep-dive into complement gene associations with AD; shows that Clu and CR1 account for most of the complement-related risk.
Paper authors
Sarah M Carpanini 1 2, Janet C Harwood 3, Emily Baker 1, Megan Torvell 1 2, The Gerad Consortium, Rebecca Sims 3, Julie Williams 1, B Paul Morgan 1 2
33804666
Paper authors
Alessandro Mangogna 1, Praveen M Varghese 2 3, Chiara Agostinis 1, Salman H Alrokayan 4, Haseeb A Khan 4, Cordula M Stover 5, Beatrice Belmonte 6, Anna Martorana 7, Giuseppe Ricci 1 8, Roberta Bulla 9, Uday Kishore 2
33542722
Paper authors
Alex Macpherson 1 2, Maisem Laabei 2, Zainab Ahdash 1, Melissa A Graewert 3, James R Birtley 1, Monika-Sarah Ed Schulze 1, Susan Crennell 2, Sarah A Robinson 4, Ben Holmes 1, Vladas Oleinikovas 1, Per H Nilsson 1 5 6, James Snowden 1, Victoria Ellis 1, Tom Eirik Mollnes 6 7 8, Charlotte M Deane 4, Dmitri Svergun 3, Alastair Dg Lawson 1, Jean Mh van den Elsen 2 9
33570492
Paper authors
Alyssa C Gilmore 1, Yuchun Zhang 2, H Terence Cook 1, Deborah P Lavin 1, Suresh Katti 2, Yi Wang 2, Krista K Johnson 2, SungKwon Kim 2, Matthew C Pickering 3
33129896
Paper authors
Praveen M Varghese 1 2, Valarmathy Murugaiah 1, Nazar Beirag 1, Nigel Temperton 3, Haseeb A Khan 4, Salman H Alrokayan 4, Mohammed N Al-Ahdal 5, Beatrice Nal 1, Futwan A Al-Mohanna 6, Robert B Sim 7, Uday Kishore 1
33488586
Paper authors
Chiara Agostinis 1, Andrea Balduit 2, Alessandro Mangogna 1, Gabriella Zito 1, Federico Romano 1, Giuseppe Ricci 1 3, Uday Kishore 4, Roberta Bulla 2
33505394
Paper authors
Alessandro Mangogna 1 , Beatrice Belmonte 2 , Chiara Agostinis 3 , Paola Zacchi 1 , Domenico Gerardo Iacopino 4 , Anna Martorana 5 , Vito Rodolico 5 , Deborah Bonazza 6 , Fabrizio Zanconati 6 , Uday Kishore 7 , Roberta Bulla 1
31649675

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