Recent Publications

A compilation of recent publications in the field of complement research and from members of Complement UK

The Journal Biomolecules (IF 4.1) are announcing a Special Issue focusing on a variety of aspects related to Complement in Human Disease. Original research manuscripts and reviews dealing with the topics outlined in the flyer are very welcome. For more information, please follow this link: https://www.mdpi.com/journal/biomolecules/special_issues/complement_system

Prof. Jean van den Elsen (bssjmhve@bath.ac.uk)

Dr. Maisem Laabei (ml418@bath.ac.uk)
Guest Editors

Paper reference

Prognostic Value of Complement Properdin in Cancer

Paper authors

Alessandro Mangogna 1, Praveen M Varghese 2 3, Chiara Agostinis 1, Salman H Alrokayan 4, Haseeb A Khan 4, Cordula M Stover 5, Beatrice Belmonte 6, Anna Martorana 7, Giuseppe Ricci 1 8, Roberta Bulla 9, Uday Kishore 2

33542722

Paper reference

The allosteric modulation of complement C5 by knob domain peptides

Paper authors

Alex Macpherson 1 2, Maisem Laabei 2, Zainab Ahdash 1, Melissa A Graewert 3, James R Birtley 1, Monika-Sarah Ed Schulze 1, Susan Crennell 2, Sarah A Robinson 4, Ben Holmes 1, Vladas Oleinikovas 1, Per H Nilsson 1 5 6, James Snowden 1, Victoria Ellis 1, Tom Eirik Mollnes 6 7 8, Charlotte M Deane 4, Dmitri Svergun 3, Alastair Dg Lawson 1, Jean Mh van den Elsen 2 9

33570492

Paper reference

Complement activity is regulated in C3 glomerulopathy by IgG-factor H fusion proteins with and without properdin targeting domains

Paper authors

Alyssa C Gilmore 1, Yuchun Zhang 2, H Terence Cook 1, Deborah P Lavin 1, Suresh Katti 2, Yi Wang 2, Krista K Johnson 2, SungKwon Kim 2, Matthew C Pickering 3

33129896

Paper reference

C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus

Paper authors

Praveen M Varghese 1 2, Valarmathy Murugaiah 1, Nazar Beirag 1, Nigel Temperton 3, Haseeb A Khan 4, Salman H Alrokayan 4, Mohammed N Al-Ahdal 5, Beatrice Nal 1, Futwan A Al-Mohanna 6, Robert B Sim 7, Uday Kishore 1

33488586

Paper reference

Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target

Paper authors

Chiara Agostinis 1, Andrea Balduit 2, Alessandro Mangogna 1, Gabriella Zito 1, Federico Romano 1, Giuseppe Ricci 1 3, Uday Kishore 4, Roberta Bulla 2

33505394

Paper reference

Prognostic Implications of the Complement Protein C1q in Gliomas.

Paper authors

Alessandro Mangogna 1 , Beatrice Belmonte 2 , Chiara Agostinis 3 , Paola Zacchi 1 , Domenico Gerardo Iacopino 4 , Anna Martorana 5 , Vito Rodolico 5 , Deborah Bonazza 6 , Fabrizio Zanconati 6 , Uday Kishore 7 , Roberta Bulla 1

31649675

Paper reference

Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration

Paper authors

Thomas M. Hallam; Kevin J. Marchbank; Claire L. Harris; Clive Osmond; Victoria G. Shuttleworth; Helen Griffiths; Angela J. Cree; David Kavanagh; Andrew J. Lotery

32516404

Paper reference

Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies

Paper authors

Praveen Mathews Varghese 1, Anthony G Tsolaki 2, Hadida Yasmin 3, Abhishek Shastri 4, Janez Ferluga 2, Manu Vatish 5, Taruna Madan 6, Uday Kishore 7

33130519

Paper reference

The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy

Paper authors

Nilufar Kadkhodayi-Kholghi1, Jayesh S. Bhatt1, Jayesh Gor2, Lindsay C. McDermott3, Daniel P Gale4 and Stephen J. Perkins5*