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Using antibodies as templates to develop small molecule anti-complement drugs to deliver to Alzheimer’s brain.
This project will test the idea that inhibiting MAC formation can reduce brain inflammation and subsequent brain degeneration in AD.
You will target MAC in order to block the “hole-punching” activity most harmful to our own cells and the most inflammatory part of complement system, while leaving the white cell-provoking activity of complement intact and available to kill bacteria.
This Alzheimer’s Society PhD studentship includes a stipend (£15,000 per year), university PhD fees at UK rates, consumables & equipment, and conference dissemination support.
Starting date: 3 October 2022.
More info: https://www.findaphd.com/phds/project/using-antibodies-as-templates-to-develop-small-molecule-anti-complement-drugs-to-deliver-to-alzheimer-s-brain/?p144901
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